Objective: The investigation evaluated the effect of the maximal oppositions approach on treated and untreated speech sounds when delivered via telelpractice. The primary dependent variable (DV) was percent accuracy of the treated sound. The secondary DVs measured generalization to untreated word positions and untreated sounds. Method: Two participants, ages 7;4 (P1) and 5;3 (P2), with severe SSDs received treatment in an A-B-A-B withdrawal design. P1 received two 20-minute sessions per week for 17 sessions, and P2 received two 15-minute sessions per week for eight sessions. The dose was 50 trials per session. Sessions occurred via telepractice. Results: P1’s treatment data revealed a stable baseline and accelerating trends only during treatment (B) phases. Upon withdrawal of the treatment (A2), data dropped in level and became zero-celerating, suggesting the maximal oppositions treatment was the cause for improvement in B1. P1 experienced a 40% gain from session four to session 17. In contrast, P2’s data trends were zero-celerating in all phases; P2’s treated sound did not improve. P2 did improve the accuracy of three untreated sounds 33%, while P1’s untreated sounds did not improve from pre- to post-investigation. Conclusion: Constrasting results between participants make conclusions difficult. The approach had a treatment effect on each participant, but in different areas. P1 improved accuracy on the treated sound; P2 improved accuracy on untreated sounds. Limitations and future directions for research are discussed.