Objective: The objective of this study was to determine if myofascial release, performed on the head, neck, and face of nurses in skilled nursing facilities, affects cognitive function, specifically memory, and attention. Method: This was a single case research design, with myofascial release on the head, neck, and face as the independent, and five-word recall as the dependent variable. Results: The participant’s ability to recall five-word sequences improved during the intervention and withdrawal phases, compared to the baseline phase, in terms of overall accuracy, but also in the rate of response, which was not anticipated. Conclusion: Myofascial release appeared to have a direct effect on the immediate recall of five-word sequences.