Occupational therapists are confronted with the need to adapt their practice to provide effective and client-centered services due to increasing diversity in the United States (U.S.) population. With an ever-growing Asian community in the U.S., cultural competency training is essential to ensure that Asian clients receive appropriate and high-quality health services. Several researchers argued that most of the occupational therapy assessment and intervention tools are designed under Western cultural norms. The literature review indicated that practicing clinicians are either not aware of the need of the culturally sensitive practice or they need the training to cater to the healthcare needs of people from diverse backgrounds. This paper discusses cultural beliefs, the perception of health and illness, and the meaning of occupation from the viewpoint of Asian clients. It aims to devise strategies for occupational therapy (OT) professionals to ensure they provide effective and culturally responsive services to these clients.