Knowledge of anatomy and kinesiology is considered a key component of OT education; however, there is no consensus of how these topics should be taught in OT programs. One approach with growing evidence is an occupation-based approach with a goal of increasing student’s understanding of occupation and application of knowledge. Additionally, there is growing evidence supporting active-learning models to promote general student satisfaction and knowledge. The purpose of this education capstone project was to address the discrepancy between current anatomy teaching practices and proven benefits of occupation-based and active-learning course materials through the development, implementation, and evaluation of a blended active-learning and occupation-based anatomy and kinesiology curricula for OT students.