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Speech sound disorder (SSD) is the most common diagnosis made by speech-language pathologists with a pediatric caseload (ASHA, 2014). An estimated 2% to 25% of children ages 5 to 7 years have a SSD diagnosis (Law, Boyle, Harris, Harkness, & Nye, 2000). This investigation examined the effects of the multiple oppositions therapy approach, contrastive method of phonological intervention administered by a speech-language pathologist to children with moderate-to-severe phonological disorders. Previous investigations supports that children with moderate-to-severe phonological disorders benefit from the multiple oppositions approach (Cathelle & Ruscello, 2004; Liles & Williams, 2006; Williams 2000a, 2000b). Multiple oppositions approach has been introduced and researched in recent years showing an efficient and effective way to remediate moderate-to-severe phonological disorders through contrasting multiple sounds simultaneously (Williams, 2000). Unlike other phonological treatment methods, the multiple opposition approach homonymy is a central theoretical tenant (Williams, 2010). The purpose of this research investigation is (a) to confirm previous claims regarding the effectiveness of the use of the multiple oppositions approach for improving sound errors with children with SSD, and (b) to improve understanding of the importance of the proper phonological analysis and selecting appropriate sound targets. A single-subject A-B research design was used to determine the effectiveness of the multiple oppositions approach. Research was conducted using three preschool age participants in the public school setting. The data were analyzed using visual inspection and the Two Standard Deviation Band method. The results revealed slight improvement in production of speech sound targets in all participants.