Depression has the potential to negatively affect quality of life. Medication non-adherence is a common emerging concern in healthcare contributing to poor outcomes. Patients with mental illness may require additional observation, direction, information, and investigation. Reiterating the importance of routine follow-up visits and compliance with recommended medication regimen can promote positive outcomes. This is an important topic as according to the Centers for Disease Control and Prevention individuals ages 15 to 24 are at an increased risk of committing suicide even more specifically individuals ages 18 to 24. The identified clinical issue is assessing medication non-adherence in patients with diagnoses of depression.