Understanding determinants for weight-loss is a national priority. Obesity is an epidemic with serious health consequences. Most of today’s obesity and overweight problems are being attributed to poor diets and not enough physical activity. These problems show no signs of slowing down with the behaviors of most Americans. The phenomenon of “The Biggest Loser” has spawned many variants in commercial health clubs. This prospectus study examined the direct and interactive or moderated effects of known determinants of healthy behaviors. Those determinants were conscientiousness and perceived autonomy support. Thus, the purpose of this prospective study was to examine these two determinants of adhering to a variant of “The Biggest Loser” to gain more scientific knowledge of predictors of those that are successful in such commercial programs.