The primary objective of this study was to compare a novel method of bilateral simultaneous tibial H-relfex acquisition (Hbil) with the traditional method of unilateral acquisition (Huni). Secondary objectives included assessing the reliability of H-relfex measures obtained via the Hbil method and determining the predictive value of an abnormal H/H Ratio obtained with the Hbil method compared with an abnormal side-to-side H-reflex latency difference (Hlat Diff) in the context of unilateral S1 radiculopathy. Tertiary objectives included exploring if any demographic or clinical examination items can predict an abnormal H/H Ratio and determining the ideal upper limit of normal for H/H Ratio in the clinical context of unilateral S1 radiculopathy.