Objective: This investigation aimed to evaluate the effectiveness of a mobile mindfulness application (app) on the perceived stress levels and academic resilience of undergraduate speech-language pathology (SLP) students. The participants were full-time students at a small, private, southern university, reporting moderate levels of perceived stress. Method: This investigation utilized a single-subject, A-B-A-B withdrawal design. Three participants completed this asynchronous, mobile app-based investigation. The participants used a commercially available app to complete a short mindfulness session for a total of 15 days. Sessions ranged from 6-17 minutes in duration. The dependent variable, perceived stress, was measured daily using the 10-item Perceived Stress Scale (PSS-10). Academic resilience was measured at the end of each phase using the Academic Resilience Scale-30. Results: Results were mixed for both perceived stress and academic resilience among participants. Statistical significance was found in some but not all participants in reducing stress as compared to baseline and withdrawal scores. Conclusion: Results were inconclusive as to whether or not a app-based mindfulness intervention is effective in reducing perceived stress and increasing academic resilience in undergraduate SLP students. These findings indicate that further research needs to be conducted but that app-based mindfulness may be a potential solution to help combat the notable problem of chronic stress reported by undergraduate speech-language pathology students.