Students with disabilities face many obstacles throughout the school environment that impact their successful participation in school related activities. Promoting opportunities for participation while removing or eliminating barriers require occupational therapists and educators to develop collaborative partnerships to maximize the student-environmental fit. The Frame of References to Enhance Childhood Occupations can be used to inform the school-based occupational therapy practitioner’s decisions regarding evidence-based strategies that can be incorporated into the school routine based on the needs of the individual student. Research studies that support collaborative partnerships and supports providing interventions within the child’s natural environment is discussed in this capstone. The aim of this capstone project is to increase the awareness of the role of school-based occupational therapy in improving participation in school related activities for students with disabilities.