Individuals who have experienced a cerebrovascular accident (CVA) are often left with unilateral upper-extremity motor deficits which typically results in dramatic decreases in overall functional ability. This manuscript will examine the importance of sensory input for motor function, the neural mechanisms underlying sensorimotor integration, and how sensory input may affect post-stroke recovery. Additionally, the evidence of current sensorimotor interventions for post-stroke rehabilitation will be evaluated and discussed. Finally, the potential of novel protocols for promoting and leveraging sensorimotor plasticity will be visited. Through a more comprehensive examination regarding the fundamentals of motor movements, therapists can better understand the gaps across common intervention strategies as it relates to stroke rehabilitation.