Spirituality, beliefs, and values are essential client factors that are recognized by the American Occupational Therapy Association’s (AOTA) Occupational Therapy Practice Framework: Domain and Process, Framework III. These client factors contribute to the meaning and quality of life. Spirituality influences a person’s motivation to interact with the environment and engage in occupational performance activities. Spirituality has a unique meaning to every client; therefore, it should be explored from the client’s point of view. Frequently spirituality improves coping mechanisms and buffers emotional distress associated with illness. It can be considered a resource for overall wellness and mental health. Occupational therapists may be uncomfortable or unaware as to how to incorporate the client’s spiritual needs into treatment. As it is a powerful force in the lives of many people, the concept of spirituality should not be ignored or overlooked in occupational therapy. Increasing awareness of the importance of spirituality’s role in client wellness is essential to holistic client-centered occupational therapy practice. The capstone will educate occupational therapy practitioners in exploring spirituality’s effect on coping skill, anxiety, depression, and the overall healing process through the development of a manuscript, thereby enhancing client care. Evidence-based practice is utilized to support the importance of including spirituality in occupational therapy to assist clients in maximizing their quality of life and occupational engagement.