With the aging United States (U.S.) population and prevalence of Alzheimer’s disease, older adult cognitive health is quickly becoming a national public health concern. Holistic occupation-based evaluation and intervention in the right place, at the right time in the health care process, are vitally important to improve the well-being and quality of life for older adults with Alzheimer’s disease and their family caregivers at home. In the U.S., several federal initiatives including The Healthy Brain Initiative: A National Public Health Road Map to Maintaining Cognitive Health discuss the economic strain and social impact of Alzheimer’s disease which demands the attention and involvement of occupational therapy. Evidence-based practice requires use of empirically studied performance assessments and multicomponent interventions for people with mild or early-stage Alzheimer’s disease within context of everyday living environments for optimal client role participation to intervene successfully with this population.