This capstone project designs a 30-credit elective course syllabus in hand therapy practice using a hybrid/blended learning approach. The course teaches occupational therapy (OT) students clinical reasoning, assessment and occupation-based and evidence-based practice assessments and interventions that pertain to hand therapy. It builds on the student’s core knowledge of OT and includes learning activities that build performance skills. It incorporates evidence-based practice and interventions that follow the American Occupational Therapy Association’s (AOTA) Practice Framework. The paper provides evidence that supports incorporating occupation-based assessments and interventions in hand therapy education.