The proposed manuscript attempts to explore the gap in literature and practice regarding pediatric populations and hand therapy rehabilitation. Pediatric populations require special attention and creative rehabilitation methods to promote functional, client-centered outcomes. There is an equally important need for hand therapists to not only understand the nuances of upper extremity treatment and interventions, but also to recognize the vast differences between pediatric and adult hand therapy patients, including developmental stages and the subsequent protocol variations, family interaction, and other stakeholder concerns. This manuscript intends to contribute to the literature regarding the pediatric client with upper extremity diagnoses and the role that evidence-based hand therapy plays in rehabilitation for children and their families.