Low testosterone (LT) levels affect approximately four million men in the United States, but only about 5% receive treatment. Testosterone is the most important male sex hormone. It helps the body produce and maintain adult male features. Testosterone deficiency syndrome can cause significant morbidity and substantial reduction in quality of life. Testosterone therapy can be safe if appropriate evaluation is done prior to treatment and during therapy. Basin et al. and Darby and Anawalt emphasized that there is a need for a standardized plan for men receiving testosterone replacement therapy. Drug manufacturers are bringing this issue to the public’s attention through direct-to-consumer advertisement. Due to aggressive marketing to the public, it is urgent that an evidence-based protocol be implemented as an increasing number of men will be inquiring about testosterone replacement. The project addressed the question: Do adult males with testosterone deficiency syndrome received appropriate evaluation pre and post initiation of testosterone replacement therapy?