Cancer is a disease marked by the uncontrolled development and spread of body cells to different areas of the body, and it is the major cause of mortality globally. Screening has been identified as an efficacious means to lower cancer mortality and morbidity. Colorectal cancer (CRC) usually emerges from precancerous polyps found inside the colorectal cancer. Therefore, screening is essential because it can detect polyps that are precancerous, allowing for their elimination before they can develop into cancer. Nationally, the CRC screening rate is low. However, compared to the national CRC screening rate, the screening rate in Federally Qualified Health Centers (FQHCs) is very low. The population of patients seen in FQHCs is minority populations who are from low socioeconomic backgrounds. The project site is an FQHC called Berks Community Health Center (BCHC), located in Reading, Pennsylvania, and mostly serves Berks County. The current CRC screening rate of BCHC is low, and the scholarly project goal is to improve the Primary Care Providers’ (PCPs) knowledge and practice regarding screening for this disease and increase the CRC screening rate. The scholarly project aimed to determine the effectiveness of a process change focused on implementing the American Cancer Society Guideline for Colorectal Cancer Screening, offering more than one CRC screening method and promoting patient reminder in improving providers’ knowledge and practice regarding screening for this disease and increasing the screening rate of BCHC.